What is SS-31?
SS-31, also known as Elamipretide (MTP-131), is a synthetic mitochondria-targeted tetrapeptide being studied for its effects on mitochondrial structure and function. Research has focused particularly on its interaction with cardiolipin in the inner mitochondrial membrane.
How does SS-31 work?
SS-31 is designed to target mitochondria and interact with cardiolipin, a phospholipid found in the inner mitochondrial membrane. Research suggests this interaction may influence mitochondrial membrane organization, bioenergetics and oxidative processes.
What is SS-31 used for in research?
SS-31 has been investigated in research involving mitochondrial dysfunction, mitochondrial myopathy, cardiovascular function, muscle function and age-related conditions. Human clinical trials have examined elamipretide in several mitochondrial disorders, while substantial additional evidence comes from preclinical research.
Is SS-31 a mitochondrial peptide?
Yes. SS-31 is classified as a mitochondria-targeted peptide. Its ability to selectively interact with mitochondrial membranes is a major focus of ongoing scientific research.
What is the difference between SS-31 and Elamipretide?
There is generally no difference in the compound itself. SS-31, Elamipretide and MTP-131 are names used to refer to the same mitochondria-targeted peptide in scientific and clinical literature.
Has SS-31 been studied in humans?
Yes. Elamipretide has been evaluated in human clinical trials, including studies investigating primary mitochondrial myopathy and other mitochondrial disorders. Results have varied by study and indication, so SS-31 remains an area of ongoing research.
Is SS-31 approved for general medical use?
SS-31/Elamipretide has been investigated as an experimental therapeutic and is not something that should be represented as an established treatment for general health or disease based solely on research findings. Clinical development and evaluation have continued across several indications.
Why is SS-31 of interest in mitochondrial research?
Mitochondria play a central role in cellular energy production. SS-31 has attracted research interest because it specifically targets the mitochondrial inner membrane and may influence cardiolipin organization, mitochondrial bioenergetics and oxidative stress pathways.
Is SS-31 suitable for research purposes?
SS-31 is commonly discussed within laboratory and scientific research relating to mitochondrial biology. Research materials should be handled and used according to applicable laboratory, regulatory and safety requirements.