Dex Pharma NAD+ Max 1000mg/3mL Pen

• Advanced Mitochondrial Support: Directly fuels the "powerhouses" of your cells to maximize systemic energy and ATP production.
• DNA Repair & Longevity: Activates critical PARP enzymes and Sirtuins (SIRT1) to repair cellular damage and protect your genetic blueprint.
• Neurocognitive Enhancement: Rapidly clears brain fog, sharpens memory, and provides neuroprotective benefits for long-term brain health.
• Instant Bioavailability: Bypasses the liver and digestive system for 100% absorption, delivering results far superior to oral NMN or NR.
• Metabolic Optimization: Increases insulin sensitivity and helps regulate the master switches of fat oxidation and glucose management.
• Circadian Rhythm Regulation: Helps reset your internal clock, leading to deeper, more restorative sleep and improved morning alertness.
• Inflammation Reduction: Works to lower systemic oxidative stress, helping to soothe joint discomfort and chronic inflammatory markers.
• Convenient Precision Dosing: The 1000mg pen format allows for ultra-precise titration, making it easy to find your perfect daily or weekly dose.

• Dosage: Common research ranges from 25mg up to 100mg per dose, 2–3 times per week. (, 25mg would be roughly 63 clicks, though most users start much lower with NAD+).
• Titration: Start with 25–50mg (approx. 63–125 clicks) to assess your "flush" tolerance. If you feel comfortable after 2 weeks, you can move toward 75–100mg.
• Usage: Inject subcutaneously in the morning only to avoid sleep disruption. Inject slowly to minimize any temporary chest pressure or nausea.
• Cycle: Run for 3 months followed by a 1-month break to maintain natural production pathways.

• What is NAD+? A vital coenzyme found in all living cells, essential for energy production, DNA repair, and healthy aging.
• Why use a pen instead of pills? Injections bypass the digestive system for 100% bioavailability, providing much higher concentrations than oral supplements.
• What are the main benefits? Increased energy, improved cognitive function, better sleep quality, and enhanced mitochondrial health.
• How do I use this pen? Administer via a quick subcutaneous injection, usually in the abdomen or thigh.
• When is the best time to inject? Always in the morning. NAD+ is energizing and can disrupt sleep if taken later in the day.
• What is the "NAD+ flush"? A temporary sensation of warmth, chest pressure, or nausea. It is harmless and usually fades within 10–20 minutes.
• How can I reduce the flush? Inject the dose very slowly and stay well-hydrated before administration.
• What is the recommended dosage? Typical research doses are 25mg to 100mg, administered 2–3 times per week.
• How long does one pen last? Depending on your dose, a 1000mg pen typically lasts 4 to 8 weeks.
• Does it need to be refrigerated? Yes, keep the pen in the fridge (2°C–8°C) to maintain the stability of the NAD+.
• What is the shelf life? Once in use, the pen remains potent for up to 60 days if kept refrigerated and sanitized.
• Should I cycle NAD+? Yes, a common protocol is 3 months on followed by a 1-month break to support endogenous production.
• Can I stack this with other peptides? Absolutely. It pairs exceptionally well with BPC-157 for recovery or GLP-1s for metabolic health.
• Are there any specific supplements to take with it? TMG (Trimethylglycine) is highly recommended to support methylation during NAD+ therapy.

NAD+, short for nicotinamide adenine dinucleotide, is a naturally occurring coenzyme found in every living cell. It plays a central role in cellular energy production, mitochondrial function, DNA repair, redox balance, and healthy ageing pathways. NAD+ works closely with NADH as part of the body’s energy-transfer system, helping cells convert nutrients into usable energy.

NAD+ is widely researched in ageing, metabolism, cardiovascular health, mitochondrial function, inflammation, and neurobiology. However, it is important to note that much of the human evidence involves NAD+ precursors, such as nicotinamide riboside / NR and nicotinamide mononucleotide / NMN, rather than direct NAD+ injections or infusions. NAD+ is currently being researched and should not be presented as an approved treatment for anti-ageing, fatigue, addiction, weight loss, or disease reversal.

1. NAD+ and cellular energy — mitochondrial and metabolic research

A major review published in Cell Metabolism explains how NAD+ helps regulate energy metabolism, mitochondrial function, and communication between the mitochondria and nucleus. The review describes NAD+ as a key metabolic cofactor involved in sirtuin activity, mitochondrial fitness, and cellular adaptation to energy stress.

Original article:

https://www.cell.com/cell-metabolism/fulltext/S1550-4131%2815%2900266-1

2. Human NAD+ IV pilot study — changes in plasma and urine metabolites

A pilot human study published in Frontiers in Aging Neuroscience investigated what happens to NAD+ and its metabolites during a 6-hour intravenous NAD+ infusion. The study documented changes in plasma and urine NAD+ metabolites during and after infusion, helping researchers better understand the fate of directly infused NAD+ in humans. This was a pilot pharmacokinetic-style study and did not prove clinical benefits for anti-ageing, energy, addiction, or disease treatment.

Original article:

https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2019.00257/full

3. Nicotinamide riboside / NR — raises NAD+ in healthy middle-aged and older adults

A randomised, double-blind, placebo-controlled crossover trial published in Nature Communications found that chronic supplementation with nicotinamide riboside, an NAD+ precursor, was well tolerated and increased NAD+ metabolism in healthy middle-aged and older adults. This is one of the better-known human studies showing that NAD+ levels can be increased through precursor supplementation.

Original article:

https://www.nature.com/articles/s41467-018-03421-7

PubMed listing:

https://pubmed.ncbi.nlm.nih.gov/29599478/

4. NMN and insulin sensitivity — prediabetic women study

A study published in Science investigated nicotinamide mononucleotide / NMN, another NAD+ precursor, in postmenopausal women with prediabetes who were overweight or obese. The study reported that NMN increased muscle insulin sensitivity, insulin signalling, and muscle remodelling markers. This supports metabolic research interest in NAD+ precursors, although it does not mean NAD+ or NMN is an approved treatment for diabetes.

Original article:

https://www.science.org/doi/10.1126/science.abe9985

PubMed listing:

https://pubmed.ncbi.nlm.nih.gov/33888596/

Full article on PubMed Central:

https://pmc.ncbi.nlm.nih.gov/articles/PMC8550608/

5. NMN and physical performance — older men study

A clinical study published in npj Aging investigated chronic oral NMN supplementation in healthy older men. The study reported partial improvements in muscle strength and physical performance markers, while also noting that more research is needed to confirm wider anti-ageing benefits. This is useful research for the NAD+ field, but it involved oral NMN rather than direct NAD+ injection.

Original article:

https://pmc.ncbi.nlm.nih.gov/articles/PMC9158788/

6. Clinical evidence review — promising but still early

A review on clinical evidence for targeting NAD+ therapeutically concluded that NAD+ biology is highly promising, especially because NAD+ is involved in ageing, metabolism, and mitochondrial function. However, the review also makes clear that many benefits seen in animal studies have not yet been fully confirmed in large, long-term human trials.

Original review article:

https://pmc.ncbi.nlm.nih.gov/articles/PMC7558103/

7. NAD+ and cardiovascular ageing research

A review published in Circulation discussed NAD+ metabolism in cardiac health, ageing, and disease. It noted that NAD+ pools tend to decline with normal ageing, obesity, and hypertension, and that NAD+ restoration is being investigated in cardiovascular research. This supports the scientific interest in NAD+ pathways, but it should not be used to claim that NAD+ treats heart disease.

Original article:

https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.056589

Quick Research Summary

Current research suggests that NAD+ is central to cellular energy, mitochondrial function, DNA repair, redox balance, and healthy ageing pathways. Human studies show that NAD+ precursors such as NR and NMN can increase NAD+ metabolism and may influence certain metabolic or physical-performance markers. Direct NAD+ infusion has also been studied in humans, but mostly in small pilot studies focused on metabolism and tolerability rather than proven clinical outcomes.